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To examine the effect of adjuvant corticosteroid therapy versus placebo on mortality, hearing loss and neurological sequelae in people of all ages with acute bacterial meningitis, we conducted a retrospective cohort study from September 2014 to March 2015 in Quebec, Canada. METHODS: A cohort of 627 persons (2,865 men (1,069/2,865), and 4,844 women (2,933/3,164)) who had meningitis or had symptoms of meningitis (including symptoms of meningitis), was recruited and enrolled in an end-stage management program, can anabolic steroids cause diabetes. Their mean age was 39, can anabolic steroids cause gyno.0 years, and 68, can anabolic steroids cause gyno.8% (1,071 of 2,865) were men, can anabolic steroids cause gyno. Men were treated with an average amount of 16 to 23 courses of prednisone (mean: 7.8; standard deviation: 2.0), with some being prescribed 3 or 4 prednisone cycles. The risk of adverse events was considered similar among the prednisone vs placebo group at 18 weeks, after 36 weeks, and after 180 weeks. We defined a nonfatal outcome for neurological sequelae as either an adverse event (e, can anabolic steroids cause lower back pain.g, can anabolic steroids cause lower back pain., hearing loss) or an outpatient outpatient hospital admission at least 4 weeks after the diagnosis of meningitis, but no longer than 24 weeks after the onset of meningitis, can anabolic steroids cause lower back pain. RESULTS: Of the 4,844 persons (2,934 of 2,865), 2,996 (59.0%) were assigned to the active treatment; 1,933 (21.0%) to the placebo assignment, with an adjusted hazard ratio of mortality of 1.21, 95% CI: 1.10-1.36 (P < 0.001). There was no effect of prednisone, nor does the study support the hypothesis that oral prednisone prevents neurologic sequelae among long-term meningitis patients. CONCLUSION: Nonfatal outcomes and adverse events are similar in an active vs a placebo group, for dexamethasone loss hearing. Patients randomized to prednisone showed no difference in adverse events relative to those assigned to placebo. As a secondary analysis, these findings also support the hypothesis that oral corticosteroids (as compared with placebo) in patients with acute bacterial meningitis do not prevent adverse events and are not contraindicated in patients with meningitis not responding to other treatments, dexamethasone for hearing loss. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
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